Ontology highlight
ABSTRACT:
SUBMITTER: Ong ST
PROVIDER: S-EPMC4094053 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Ong Seow Theng ST Freeley Michael M Skubis-Zegadło Joanna J Fazil Mobashar Hussain Urf Turabe MH Kelleher Dermot D Fresser Friedrich F Baier Gottfried G Verma Navin Kumar NK Long Aideen A
The Journal of biological chemistry 20140528 28
Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we report a previously uncharacterized role for Rab5a in the regulation of T-cell motility. We show that Rab5a physically associates with protein kinase Cϵ (PKCϵ) in migrating T-cells. After stimulation of T-cells through the integrin LFA-1 or the chemokine receptor CXCR4, Rab5a is ...[more]