Unknown

Dataset Information

0

Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination.


ABSTRACT:

Objective

To study the neurocognitive profile and its relationship to prefrontal dysfunction in non-demented Parkinson's disease (PD) with deficient haptic perception.

Methods

Twelve right-handed patients with PD and 12 healthy control subjects underwent thorough neuropsychological testing including Rey complex figure, Rey auditory verbal and figural learning test, figural and verbal fluency, and Stroop test. Test scores reflecting significant differences between patients and healthy subjects were correlated with the individual expression coefficients of one principal component, obtained in a principal component analysis of an oxygen-15-labeled water PET study exploring somatosensory discrimination that differentiated between the two groups and involved prefrontal cortices.

Results

We found significantly decreased total scores for the verbal learning trials and verbal delayed free recall in PD patients compared with normal volunteers. Further analysis of these parameters using Spearman's ranking correlation showed a significantly negative correlation of deficient verbal recall with expression coefficients of the principal component whose image showed a subcortical-cortical network, including right dorsolateral-prefrontal cortex, in PD patients.

Conclusion

PD patients with disrupted right dorsolateral prefrontal cortex function and associated diminished somatosensory discrimination are impaired also in verbal memory functions. A negative correlation between delayed verbal free recall and PET activation in a network including the prefrontal cortices suggests that verbal cues and accordingly declarative memory processes may be operative in PD during activities that demand sustained attention such as somatosensory discrimination. Verbal cues may be compensatory in nature and help to non-specifically enhance focused attention in the presence of a functionally disrupted prefrontal cortex.

SUBMITTER: Bohlhalter S 

PROVIDER: S-EPMC2805678 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination.

Bohlhalter Stephan S   Abela Eugenio E   Weniger Dorothea D   Weder Bruno B  

Behavioral and brain functions : BBF 20091215


<h4>Objective</h4>To study the neurocognitive profile and its relationship to prefrontal dysfunction in non-demented Parkinson's disease (PD) with deficient haptic perception.<h4>Methods</h4>Twelve right-handed patients with PD and 12 healthy control subjects underwent thorough neuropsychological testing including Rey complex figure, Rey auditory verbal and figural learning test, figural and verbal fluency, and Stroop test. Test scores reflecting significant differences between patients and heal  ...[more]

Similar Datasets

| S-EPMC4874785 | biostudies-other
| S-EPMC5071112 | biostudies-other
| S-EPMC6721264 | biostudies-literature
| S-EPMC9243420 | biostudies-literature
| S-EPMC6581739 | biostudies-literature
| S-EPMC9254338 | biostudies-literature
| S-EPMC4632206 | biostudies-literature
| S-EPMC2997155 | biostudies-literature
| S-EPMC8478201 | biostudies-literature
| S-EPMC3661504 | biostudies-other