Ontology highlight
ABSTRACT:
SUBMITTER: Sen M
PROVIDER: S-EPMC2805860 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Sen Mehmet M Herzik Mark M Craft John W JW Creath Andrea L AL Agrawal Sameer S Ruf Wolfram W Legge Glen B GB
The open spectroscopy journal 20090101
Tissue Factor (TF) is well known for its role during the activation of the coagulation pathway, but it is also critical for tumor biology and inflammation through protease activated receptor (PAR) 2 signaling. This signaling function is modulated by the successive phosphorylation of residues Ser253 and Ser258 within the TF cytoplasmic region (TFCR). This paper reports how we used NMR and spectroscopic methods to investigate the structural propensities of the unphosphorylated and phosphorylated f ...[more]