Ontology highlight
ABSTRACT:
SUBMITTER: Lee HS
PROVIDER: S-EPMC2912352 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Lee Ho-Sup HS Komarova Yulia A YA Nadezhdina Elena S ES Anjum Rana R Peloquin John G JG Schober Joseph M JM Danciu Oana O van Haren Jeffrey J Galjart Niels N Gygi Steven P SP Akhmanova Anna A Borisy Gary G GG
Molecular biology of the cell 20100602 15
Cytoplasmic linker protein (CLIP)-170 is a microtubule (MT) plus-end-tracking protein that regulates MT dynamics and links MT plus ends to different intracellular structures. We have shown previously that intramolecular association between the N and C termini results in autoinhibition of CLIP-170, thus altering its binding to MTs and the dynactin subunit p150(Glued) (J. Cell Biol. 2004: 166, 1003-1014). In this study, we demonstrate that conformational changes in CLIP-170 are regulated by phosph ...[more]