Ontology highlight
ABSTRACT:
SUBMITTER: Robbiani DF
PROVIDER: S-EPMC2805907 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Robbiani Davide F DF Bunting Samuel S Feldhahn Niklas N Bothmer Anne A Camps Jordi J Deroubaix Stephanie S McBride Kevin M KM Klein Isaac A IA Stone Gary G Eisenreich Thomas R TR Ried Thomas T Nussenzweig André A Nussenzweig Michel C MC
Molecular cell 20091101 4
Cancer-initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces widespread somatic mutation in mature B cells; however, the extent of "off-target" DSB formation and its role in translocation-associated malignancy is unknown. Here, we show that deregulated expression of AID causes widespread genome instability, which alone is insufficient to induce B cell lymphoma; transf ...[more]