Ontology highlight
ABSTRACT:
SUBMITTER: Ren Y
PROVIDER: S-EPMC2806190 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Ren Yi Y Yip Calvin K CK Tripathi Arati A Huie David D Jeffrey Philip D PD Walz Thomas T Hughson Frederick M FM
Cell 20091201 6
Vesicle trafficking requires membrane fusion, mediated by SNARE proteins, and upstream events that probably include "tethering," an initial long-range attachment between a vesicle and its target organelle. Among the factors proposed to mediate tethering are a set of multisubunit tethering complexes (MTCs). The Dsl1 complex, with only three subunits, is the simplest known MTC and is essential for the retrograde traffic of COPI-coated vesicles from the Golgi to the ER. To elucidate structural prin ...[more]