Ontology highlight
ABSTRACT:
SUBMITTER: Treinin M
PROVIDER: S-EPMC28070 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
Treinin M M Gillo B B Liebman L L Chalfie M M
Proceedings of the National Academy of Sciences of the United States of America 19981201 26
The deg-3 gene from the nematode Caenorhabditis elegans encodes an alpha subunit of a nicotinic acetylcholine receptor that was first identified by a dominant allele, u662, which produced neuronal degeneration. Because deg-3 cDNAs contain the SL2 trans-spliced leader, we suggested that deg-3 was transcribed as part of a C. elegans operon. Here we show that des-2, a gene in which mutations suppress deg-3(u662), is the upstream gene in that operon. The des-2 gene also encodes an alpha subunit of a ...[more]