Ontology highlight
ABSTRACT:
SUBMITTER: Guy CP
PROVIDER: S-EPMC2807033 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Guy Colin P CP Atkinson John J Gupta Milind K MK Mahdi Akeel A AA Gwynn Emma J EJ Rudolph Christian J CJ Moon Peter B PB van Knippenberg Ingeborg C IC Cadman Chris J CJ Dillingham Mark S MS Lloyd Robert G RG McGlynn Peter P
Molecular cell 20091101 4
Nucleoprotein complexes present challenges to genome stability by acting as potent blocks to replication. One attractive model of how such conflicts are resolved is direct targeting of blocked forks by helicases with the ability to displace the blocking protein-DNA complex. We show that Rep and UvrD each promote movement of E. coli replisomes blocked by nucleoprotein complexes in vitro, that such an activity is required to clear protein blocks (primarily transcription complexes) in vivo, and tha ...[more]