Ontology highlight
ABSTRACT:
SUBMITTER: Lee HY
PROVIDER: S-EPMC2807416 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Lee Hyang-Yeol HY Yerkes Nancy N O'Connor Sarah E SE
Chemistry & biology 20091201 12
Biosynthetic pathways can be hijacked to yield novel compounds by introduction of novel starting materials. Here we have altered tryptamine, which serves as the starting substrate for a variety of alkaloid biosynthetic pathways, by replacing the indole with one of four aza-indole isomers. We show that two aza-tryptamine substrates can be successfully incorporated into the products of the monoterpene indole alkaloid pathway in Catharanthus roseus. Use of unnatural heterocycles in precursor-direct ...[more]