Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC2807601 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Tong Ying Y Xu Ying Y Scearce-Levie Kimberly K Ptácek Louis J LJ Fu Ying-Hui YH
Neurogenetics 20090623 1
Collagen XXV alpha 1 (COL25A1) is a collagenous type II transmembrane protein purified from senile plaques of Alzheimer's disease (AD) brains. COL25A1 alleles have been associated with increased risk for AD in a Swedish population. COL25A1 is specifically expressed in neurons and binds to aggregated Abeta in vitro. However, its contribution to the pathogenesis of AD and in vivo function are unknown. Here, we report that over-expression of COL25A1 in transgenic mice increases p35/p25 and beta-sit ...[more]