In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.
Ontology highlight
ABSTRACT: Introduction
The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.Methods
We estimated cortical thickness, tau ([18F]-AV-1451), and amyloid ? (A?) status ([11C]-PiB) in 47 subjects who were stratified into A?- (14 healthy controls and six mild cognitive impairment-A?-) and A?+ (14 mild cognitive impairment-A?+ and 13 AD) groups.Results
Compared with the A?- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each A? group. Locally, regional tau was associated with temporoparietal atrophy.Discussion
These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD.
SUBMITTER: Mak E
PROVIDER: S-EPMC6222030 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.
Mak Elijah E Bethlehem Richard A I RAI Romero-Garcia Rafael R Cervenka Simon S Rittman Timothy T Gabel Silvy S Surendranathan Ajenthan A Bevan-Jones Richard W RW Passamonti Luca L Vázquez Rodríguez Patricia P Su Li L Arnold Robert R Williams Guy B GB Hong Young T YT Fryer Tim D TD Aigbirhio Franklin I FI Rowe James B JB O'Brien John T JT
Alzheimer's & dementia (Amsterdam, Netherlands) 20180917
<h4>Introduction</h4>The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.<h4>Methods</h4>We estimated cortical thickness, tau ([<sup>18</sup>F]-AV-1451), and amyloid β (Aβ) status ([<sup>11</sup>C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mi ...[more]
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