Ontology highlight
ABSTRACT:
SUBMITTER: Hezel M
PROVIDER: S-EPMC2808226 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20091125 2
The molecular mechanisms that regulate the organization and activity of the neuromuscular junction remain to be fully identified. Caveolae are invaginations of the plasma membrane. Caveolin-3 is the structural protein component of caveolae in muscle cells. We show that caveolin-3 is expressed at the neuromuscular junction, that it associates with the nicotinic acetylcholine receptor (nAChR), and that a lack of caveolin-3 inhibits clustering of the nAChR in myotubes. At the molecular level, we de ...[more]