Ontology highlight
ABSTRACT:
SUBMITTER: Corti D
PROVIDER: S-EPMC2808385 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Corti Davide D Langedijk Johannes P M JP Hinz Andreas A Seaman Michael S MS Vanzetta Fabrizia F Fernandez-Rodriguez Blanca M BM Silacci Chiara C Pinna Debora D Jarrossay David D Balla-Jhagjhoorsingh Sunita S Willems Betty B Zekveld Maria J MJ Dreja Hanna H O'Sullivan Eithne E Pade Corinna C Orkin Chloe C Jeffs Simon A SA Montefiori David C DC Davis David D Weissenhorn Winfried W McKnight Aine A Heeney Jonathan L JL Sallusto Federica F Sattentau Quentin J QJ Weiss Robin A RA Lanzavecchia Antonio A
PloS one 20100120 1
<h4>Background</h4>The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are important goals that are central to the design of an effective antibody-based vaccine.<h4>Methods and findings</h4>We immortalized IgG(+) memory B cells from individuals infected with diverse clades of HIV-1 and selected on the basis of plasma neutralization profiles tha ...[more]