Ontology highlight
ABSTRACT:
SUBMITTER: Andrabi R
PROVIDER: S-EPMC3756680 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Virology 20130305 2
One approach to the development of an HIV vaccine is to design a protein template which can present gp120 epitopes inducing cross-neutralizing antibodies. To select a V3 sequence for immunogen design, we compared the neutralizing activities of 18 anti-V3 monoclonal antibodies (mAbs) derived from Cameroonian and Indian individuals infected with clade AG and C, respectively. It was found that V3 mAbs from the Cameroonian patients were significantly more cross-neutralizing than those from India. In ...[more]