Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC2808414 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Fang Xiangdong X Han Hemei H Stamatoyannopoulos George G Li Qiliang Q
The Journal of biological chemistry 20031126 7
The CCAAT box is a widespread motif in eukaryotic promoters. In this study we demonstrate that the effects of the CCAAT box on gamma-globin gene activation are developmentally distinct. Although this promoter element is essential for high level gamma gene expression in adult erythropoiesis, it plays little role in embryonic erythroid cells. The CCAAT mutation in the human gamma-globin gene promoter impairs recruitment of TATA-binding protein (TBP), TFIIB, and RNA polymerase II in adult splenic e ...[more]