Ontology highlight
ABSTRACT:
SUBMITTER: Rossi M
PROVIDER: S-EPMC2808702 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Rossi Matteo M Bang Jeong-Kyu JK Mazur Sharlyn S Iera Jaclyn A JA Phillips Darren C DC Zambetti Gerard P GP Appella Daniel H DH
Bioorganic & medicinal chemistry letters 20090321 9
Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-x(L) is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-x(L)-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-x(L). We have identified a small molecu ...[more]