Ontology highlight
ABSTRACT:
SUBMITTER: Mokany E
PROVIDER: S-EPMC2808728 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100101 3
To increase the versatility and utility of nucleic acid enzymes, we developed multicomponent complexes, known as MNAzymes, which produce amplified "output" signals in response to specific "input" signals. Multiple oligonucleotide partzymes assemble into active MNAzymes only in the presence of an input assembly facilitator such as a target nucleic acid. Once formed, MNAzymes catalytically modify a generic substrate, generating an amplified output signal that heralds the presence of the target whi ...[more]