Ontology highlight
ABSTRACT:
SUBMITTER: Escande C
PROVIDER: S-EPMC2810074 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Escande Carlos C Chini Claudia C S CC Nin Veronica V Dykhouse Katherine Minter KM Novak Colleen M CM Levine James J van Deursen Jan J Gores Gregory J GJ Chen Junjie J Lou Zhenkun Z Chini Eduardo Nunes EN
The Journal of clinical investigation 20100111 2
The enzyme sirtuin 1 (SIRT1) is a critical regulator of many cellular functions, including energy metabolism. However, the precise mechanisms that modulate SIRT1 activity remain unknown. As SIRT1 activity in vitro was recently found to be negatively regulated by interaction with the deleted in breast cancer-1 (DBC1) protein, we set out to investigate whether DBC1 regulates SIRT1 activity in vivo. We found that DBC1 and SIRT1 colocalized and interacted, and that DBC1 modulated SIRT1 activity, in ...[more]