No association between CALHM1 variation and risk of Alzheimer disease.
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ABSTRACT:
SUBMITTER: Minster RL
PROVIDER: S-EPMC2810280 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
No association between CALHM1 variation and risk of Alzheimer disease.
Minster Ryan L RL Demirci F Yesim FY DeKosky Steven T ST Kamboh M Ilyas MI
Human mutation 20090401 4
A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No association with risk of late-onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an e ...[more]
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