No consistent evidence for association between mtDNA variants and Alzheimer disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Hudson G
PROVIDER: S-EPMC3317529 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Publications
No consistent evidence for association between mtDNA variants and Alzheimer disease.
Hudson G G Sims R R Harold D D Chapman J J Hollingworth P P Gerrish A A Russo G G Hamshere M M Moskvina V V Jones N N Thomas C C Stretton A A Holmans P A PA O'Donovan M C MC Owen M J MJ Williams J J Chinnery P F PF
Neurology 20120321 14
<h4>Objective</h4>Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.<h4>Methods</h4>We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly c ...[more]
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