Ontology highlight
ABSTRACT:
SUBMITTER: Henchey LK
PROVIDER: S-EPMC2810346 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100101 3
Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for genomic research and, potentially, drug discovery efforts for the treatment of neovascularization in cancers. We report a stabilized alpha-helix designed to target the binding interface between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and cysteine-histidine rich region (CH1) of transcriptional coactivator CBP/p300. The synthetic helix disrupts the structu ...[more]