Ontology highlight
ABSTRACT:
SUBMITTER: Kim MY
PROVIDER: S-EPMC2810531 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Cell 20091201 7
Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also colonize their tumors of origin, in a process that we call "tumor self-seeding." Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, including those with bone, lung, or brain-metastatic tropism. We find that the tumor-derived cytokines ...[more]