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Circulating tumor cells in breast cancer.


ABSTRACT: Over the past decade, technically reliable circulating tumor cell (CTC) detection methods allowed the collection of large datasets of CTC counts in cancer patients. These data can be used either as a dynamic prognostic biomarker or as tumor material for "liquid biopsy". Breast cancer appears to be the cancer type in which CTC have been the most extensively studied so far, with level-of-evidence-1 studies supporting the clinical validity of CTC count in both early and metastatic stage. This review summarizes and discusses the clinical results obtained in breast cancer patients, the issues faced by the molecular characterization of CTC and the biological findings about cancer biology and metastasis that were obtained from CTC.

SUBMITTER: Bidard FC 

PROVIDER: S-EPMC5528978 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Circulating tumor cells in breast cancer.

Bidard Francois-Clement FC   Proudhon Charlotte C   Pierga Jean-Yves JY  

Molecular oncology 20160112 3


Over the past decade, technically reliable circulating tumor cell (CTC) detection methods allowed the collection of large datasets of CTC counts in cancer patients. These data can be used either as a dynamic prognostic biomarker or as tumor material for "liquid biopsy". Breast cancer appears to be the cancer type in which CTC have been the most extensively studied so far, with level-of-evidence-1 studies supporting the clinical validity of CTC count in both early and metastatic stage. This revie  ...[more]

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