Ontology highlight
ABSTRACT:
SUBMITTER: Burton JB
PROVIDER: S-EPMC2811163 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Burton Jeremy B JB Johnson Mai M Sato Makoto M Koh Sok Boon S SB Mulholland David J DJ Stout David D Chatziioannou Arion F AF Phelps Michael E ME Wu Hong H Wu Lily L
Nature medicine 20080711 8
The accurate assessment of nodal involvement in prostate cancer is crucial to planning treatment, yet there is a shortage of noninvasive imaging techniques capable of visualizing nodal lesions directly. This study demonstrates the feasibility of using recombinant human adenoviral vectors to detect nodal metastases in a human prostate cancer model. This was achieved by the prostate-restricted expression of optical and positron emission tomography (PET) imaging reporter genes by the viral vector c ...[more]