Ontology highlight
ABSTRACT:
SUBMITTER: Dong B
PROVIDER: S-EPMC2812331 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Dong Beihua B Silverman Robert H RH
Journal of virology 20091111 3
Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus originally identified in a subset of prostate cancer patients. Because androgens stimulate prostate tumors and some retroviruses, we investigated the effects of dihydrotestosterone (DHT) on XMRV transcription and replication. Transcription from the XMRV U3 region was stimulated up to 2-fold by DHT, but only in cells containing a functional androgen receptor. Mutations in the glucocorticoid response element (GRE) of XMRV i ...[more]