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Susceptibility of human primary neuronal cells to xenotropic murine leukemia virus-related (XMRV) virus infection.


ABSTRACT:

Background

Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV.

Findings

We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons were more susceptible compared with progenitor-derived astrocytes. In addition, XMRV-infected Jurkat cells were able to transmit infection to neuronal cells.

Conclusions

These data suggest that neuronal cells are susceptible for XMRV infection.

SUBMITTER: Ravichandran V 

PROVIDER: S-EPMC3192781 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Susceptibility of human primary neuronal cells to xenotropic murine leukemia virus-related (XMRV) virus infection.

Ravichandran Veerasamy V   Major Eugen O EO   Ibe Carol C   Monaco Maria Chiara MC   Girisetty Mohan Kumar Haleyur MK   Hewlett Indira K IK  

Virology journal 20110920


<h4>Background</h4>Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV.<h4>Findings</h4>We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons wer  ...[more]

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