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Identification of the Salmonella enterica damX gene product, an inner membrane protein involved in bile resistance.

ABSTRACT: The damX gene product of Salmonella enterica serovar Typhimurium is a protein located in the inner membrane. DamX migrates as a 70-kDa protein in SDS-PAGE even though the predicted protein size is 46 kDa. Synthesis of DamX protein occurs in both exponential- and stationary-phase cultures. Disruption of damX causes severe sensitivity to bile. Lack of the outer membrane protein AsmA suppresses bile sensitivity in Salmonella damX mutants.

SUBMITTER: Lopez-Garrido J

PROVIDER: S-EPMC2812469 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Identification of the Salmonella enterica damX gene product, an inner membrane protein involved in bile resistance.

López-Garrido Javier J Cheng Nancy N García-Quintanilla Fátima F García-del Portillo Francisco F Casadesús Josep J

Journal of bacteriology 20091130 3

The damX gene product of Salmonella enterica serovar Typhimurium is a protein located in the inner membrane. DamX migrates as a 70-kDa protein in SDS-PAGE even though the predicted protein size is 46 kDa. Synthesis of DamX protein occurs in both exponential- and stationary-phase cultures. Disruption of damX causes severe sensitivity to bile. Lack of the outer membrane protein AsmA suppresses bile sensitivity in Salmonella damX mutants. ...[more]

PMID: 19948803

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