Ontology highlight
ABSTRACT:
SUBMITTER: Ouellet H
PROVIDER: S-EPMC2812603 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Ouellet Hugues H Johnston Jonathan B JB Ortiz de Montellano Paul R PR
Archives of biochemistry and biophysics 20090725 1
Tuberculosis remains a leading cause of human mortality. The emergence of strains of Mycobacterium tuberculosis, the causative agent, that are resistant to the major frontline antitubercular drugs increases the urgency for the development of new therapeutic agents. Sequencing of the M. tuberculosis genome revealed the existence of 20 cytochrome P450 enzymes, some of which are potential candidates for drug targeting. The recent burst of studies reporting microarray-based gene essentiality and tra ...[more]