Ontology highlight
ABSTRACT:
SUBMITTER: Espinosa MC
PROVIDER: S-EPMC2813283 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Espinosa Maria Claudia MC Rehman Muhammad Attiq MA Chisamore-Robert Patricia P Jeffery Daniel D Yankulov Krassimir K
PloS one 20100129 1
GCN5 encodes one of the non-essential Histone Acetyl Transferases in Saccharomyces cerevisiae. Extensive evidence has indicated that GCN5 is a key regulator of gene expression and could also be involved in transcriptional elongation, DNA repair and centromere maintenance. Here we show that the deletion of GCN5 decreases the stability of mini-chromosomes; that the tethering of Gcn5p to a crippled origin of replication stimulates its activity; that high dosage of GCN5 suppresses conditional phenot ...[more]