Ontology highlight
ABSTRACT:
SUBMITTER: Chatre L
PROVIDER: S-EPMC3050842 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Chatre Laurent L Ricchetti Miria M
PloS one 20110308 3
The nuclear genome of eukaryotes is colonized by DNA fragments of mitochondrial origin, called NUMTs. These insertions have been associated with a variety of germ-line diseases in humans. The significance of this uptake of potentially dangerous sequences into the nuclear genome is unclear. Here we provide functional evidence that sequences of mitochondrial origin promote nuclear DNA replication in Saccharomyces cerevisiae. We show that NUMTs are rich in key autonomously replicating sequence (ARS ...[more]