Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
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ABSTRACT:
SUBMITTER: Julien C
PROVIDER: S-EPMC2813570 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
Julien Carl C Tremblay Cyntia C Emond Vincent V Lebbadi Meryem M Salem Norman N Bennett David A DA Calon Frédéric F
Journal of neuropathology and experimental neurology 20090101 1
Aging and metabolism-related disorders are risk factors for Alzheimer disease (AD). Because sirtuins may increase the life span through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunoblots and in situ hybridization. We report a significant reduction of SIRT1 (messenger RNA [mRNA], -29%; protein, -45%) in the parietal cortex of AD patients, but not in the cerebellum. Further anal ...[more]
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