Ontology highlight
ABSTRACT:
SUBMITTER: Csibi A
PROVIDER: S-EPMC2813880 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Csibi Alfredo A Cornille Karen K Leibovitch Marie-Pierre MP Poupon Anne A Tintignac Lionel A LA Sanchez Anthony M J AM Leibovitch Serge A SA
PloS one 20100201 2
The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E-BP1. mTOR and S6K1 are connected by interacting with the eIF3 initiation complex. The regulatory subunit eIF3f plays a major role in muscle hypertrophy and is a key target that accounts for MAFbx function during atrophy. Here we present evidence that in MAFbx-induced atrophy the degradation of eIF3f suppresses S6K1 act ...[more]