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Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

ABSTRACT: The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.

SUBMITTER: Herath A

PROVIDER: S-EPMC2814065 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

Herath Ananda A Dahl Russell R Cosford Nicholas D P ND

Organic letters 20100201 3

The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates. ...[more]

PMID: 20038130

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