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Multicomponent reaction discovery: three-component synthesis of spirooxindoles.

ABSTRACT: The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.

SUBMITTER: Liang B

PROVIDER: S-EPMC2814073 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Multicomponent reaction discovery: three-component synthesis of spirooxindoles.

Liang Bo B Kalidindi Srinivas S Porco John A JA Stephenson Corey R J CR

Organic letters 20100201 3

The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives. ...[more]

PMID: 20050598

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