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A three-component reaction forming naphthyridones--synthesis of lophocladine analogs.

ABSTRACT: A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and amines, and the produced compounds are analogs of the natural product lophocladine A.

SUBMITTER: Sellstedt M

PROVIDER: S-EPMC3203621 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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A three-component reaction forming naphthyridones--synthesis of lophocladine analogs.

Sellstedt Magnus M Almqvist Fredrik F

Organic letters 20110901 19

A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and amines, and the produced compounds are analogs of the natural product lophocladine A. ...[more]

PMID: 21879774

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