Ontology highlight
ABSTRACT:
SUBMITTER: Shiozawa Y
PROVIDER: S-EPMC2814350 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Shiozawa Yusuke Y Pedersen Elisabeth A EA Patel Lalit R LR Ziegler Anne M AM Havens Aaron M AM Jung Younghun Y Wang Jingcheng J Zalucha Stephanie S Loberg Robert D RD Pienta Kenneth J KJ Taichman Russell S RS
Neoplasia (New York, N.Y.) 20100201 2
Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bone marrow. The role of the niche is thought to be the induction and sustenance of HSC dormancy. If metastatic PCa cells occupy a similar or the same ecological niche as HSCs, then i ...[more]