The actin modulator hMENA regulates GAS6-AXL axis and pro-tumor cancer/stromal cell cooperation

ABSTRACT: The dynamic interplay between cancer cells and cancer-associated fibroblasts (CAFs) is regulated by multiple signaling pathways which can lead to cancer progression and therapy resistance. We have previously demonstrated that hMENA, a member of the actin-regulatory protein of Ena/VASP family, and its tissue specific isoforms influence a number of intracellular signaling pathways related to cancer progression. Here, we report a novel function of hMENA/hMENA?v6 isoforms in tumor-promoting CAFs and in the modulation of pro-tumoral cancer cell/CAF crosstalk via GAS6/AXL axis regulation. LC-MS/MS proteomic analysis revealed that CAF over-expressing hMENA?v6 secret the AXL ligand GAS6, favoring the invasiveness of AXL-expressing PDAC and NSCLC cells. Reciprocally, hMENA/hMENA?v6 regulate AXL e

SUBMITTER: Dr. Roberta Melchionna 

PROVIDER: S-SCDT-EMBOR-2020-50078-T | biostudies-other |

REPOSITORIES: biostudies-other