Ontology highlight
ABSTRACT:
SUBMITTER: Wen S
PROVIDER: S-EPMC2815123 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Wen Shu S Zhu Huiping H Lu Wei W Mitchell Laura E LE Shaw Gary M GM Lammer Edward J EJ Finnell Richard H RH
American journal of medical genetics. Part A 20100201 2
Spina bifida, a neural tube closure defect (NTD) involving the posterior portion of what will ultimately give rise to the spinal cord, is one of the most common and serious birth defects. The etiology of spina bifida is thought to be multi-factorial and involve multiple interacting genes and environmental factors. The causes of this congenital malformation remain largely unknown. However, several candidate genes for spina bifida have been identified in lower vertebrates, including the planar cel ...[more]