Global survey of protein expression during gonadal sex determination in mice.
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ABSTRACT:
SUBMITTER: Ewen K
PROVIDER: S-EPMC2816018 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Global survey of protein expression during gonadal sex determination in mice.
Ewen Katherine K Baker Mark M Wilhelm Dagmar D Aitken R John RJ Koopman Peter P
Molecular & cellular proteomics : MCP 20090717 12
The development of an embryo as male or female depends on differentiation of the gonads as either testes or ovaries. A number of genes are known to be important for gonadal differentiation, but our understanding of the regulatory networks underpinning sex determination remains fragmentary. To advance our understanding of sexual development beyond the transcriptome level, we performed the first global survey of the mouse gonad proteome at the time of sex determination by using two-dimensional nan ...[more]
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