Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Moreno SA
PROVIDER: S-EPMC6368449 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Garcia-Moreno S Alexandra SA Futtner Christopher R CR Salamone Isabella M IM Gonen Nitzan N Lovell-Badge Robin R Maatouk Danielle M DM
Developmental biology 20181227 2
Cis-regulatory elements are critical for the precise spatiotemporal regulation of genes during development. However, identifying functional regulatory sites that drive cell differentiation in vivo has been complicated by the high numbers of cells required for whole-genome epigenetic assays. Here, we identified putative regulatory elements during sex determination by performing ATAC-seq and ChIP-seq for H3K27ac in purified XX and XY gonadal supporting cells before and after sex determination in m ...[more]