Ontology highlight
ABSTRACT:
SUBMITTER: Fujikawa K
PROVIDER: S-EPMC2816215 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Fujikawa Keiko K Iwata Takeshi T Inoue Kaoru K Akahori Masakazu M Kadotani Hanako H Fukaya Masahiro M Watanabe Masahiko M Chang Qing Q Barnett Edward M EM Swat Wojciech W
PloS one 20100204 2
<h4>Background</h4>Glaucoma is a leading cause of blindness worldwide. Nonetheless, the mechanism of its pathogenesis has not been well-elucidated, particularly at the molecular level, because of insufficient availability of experimental genetic animal models.<h4>Methodology/principal findings</h4>Here we demonstrate that deficiency of Vav2 and Vav3, guanine nucleotides exchange factors for Rho guanosine triphosphatases, leads to an ocular phenotype similar to human glaucoma. Vav2/Vav3-deficient ...[more]