Ontology highlight
ABSTRACT:
SUBMITTER: Rhee DB
PROVIDER: S-EPMC2816614 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Rhee David B DB Wang Yisong Y Mizesko Melissa M Zhou Fang F Haneline Laura L Liu Yie Y
Human molecular genetics 20091218 5
Telomere shortening has been linked to rare human disorders that present with bone marrow failure including Fanconi anemia (FA). FANCC is one of the most commonly mutated FA genes in FA patients and the FANCC subtype tends to have a relatively early onset of bone marrow failure and hematologic malignancies. Here, we studied the role of Fancc in telomere length regulation in mice. Deletion of Fancc (Fancc(-/-)) did not affect telomerase activity, telomere length or telomeric end-capping in a mous ...[more]