Ontology highlight
ABSTRACT:
SUBMITTER: Liaw H
PROVIDER: S-EPMC3120867 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Liaw Hungjiun H Lee Deokjae D Myung Kyungjae K
PloS one 20110622 6
Hyperphosphorylation of RPA2 at serine 4 and serine 8 (S4, S8) has been used as a marker for activation of the DNA damage response. What types of DNA lesions cause RPA2 hyperphosphorylation, which kinase(s) are responsible for them, and what is the biological outcome of these phosphorylations, however, have not been fully investigated. In this study we demonstrate that RPA2 hyperphosphorylation occurs primarily in response to genotoxic stresses that cause high levels of DNA double-strand breaks ...[more]