DNA structures from phosphate chemical shifts.
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ABSTRACT:
SUBMITTER: Abi-Ghanem J
PROVIDER: S-EPMC2817473 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
DNA structures from phosphate chemical shifts.
Abi-Ghanem Joséphine J Heddi Brahim B Foloppe Nicolas N Hartmann Brigitte B
Nucleic acids research 20091126 3
For B-DNA, the strong linear correlation observed by nuclear magnetic resonance (NMR) between the (31)P chemical shifts (deltaP) and three recurrent internucleotide distances demonstrates the tight coupling between phosphate motions and helicoidal parameters. It allows to translate deltaP into distance restraints directly exploitable in structural refinement. It even provides a new method for refining DNA oligomers with restraints exclusively inferred from deltaP. Combined with molecular dynamic ...[more]
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