Ontology highlight
ABSTRACT:
SUBMITTER: Lauwaet T
PROVIDER: S-EPMC2818108 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Lauwaet Tineke T Andersen Yolanda Y Van de Ven Liesbeth L Eckmann Lars L Gillin Frances D FD
The Journal of antimicrobial chemotherapy 20100112 3
<h4>Objectives</h4>Attachment to the small intestinal mucosa is crucial for initiating and maintaining Giardia infection. We tested the effect of isoflavones on Giardia attachment.<h4>Methods</h4>We evaluated the effect of formononetin on trophozoite attachment to glass, to intestinal epithelial cell layers in vitro and to murine small intestinal explants, and on the intestinal load in mice.<h4>Results</h4>We found that the isoflavone formononetin inhibits both attachment and flagellar motility ...[more]