Ontology highlight
ABSTRACT:
SUBMITTER: Yan S
PROVIDER: S-EPMC2818252 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20091008 3
A series of novel oxazolidinone antibiotics having [2.2.1] and [2.2.2] bicyclic oxazine moieties at the C-5 side chain of the A-ring was synthesized by nitroso Diels-Alder reactions, from three linezolid analogs containing morpholine, piperazine and thiomorpholine, respectively, as the C-ring components. Subsequent N-O bond cleavage generated oxazolidinones with 4-amino cyclo-2-en-1-ol substituents. The in vitro antibacterial activities of these oxazolidinone analogs were evaluated. ...[more]