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Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.

ABSTRACT: A series of benzylidene cyclopentenedione-based inhibitors, acting through covalent modification of the active site of botulinum neurotoxin A light chain metalloprotease, are reported.

SUBMITTER: Capkova K

PROVIDER: S-EPMC2818383 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.

Capková Katerina K Hixon Mark S MS Pellett Sabine S Barbieri Joseph T JT Johnson Eric A EA Janda Kim D KD

Bioorganic & medicinal chemistry letters 20091031 1

A series of benzylidene cyclopentenedione-based inhibitors, acting through covalent modification of the active site of botulinum neurotoxin A light chain metalloprotease, are reported. ...[more]

PMID: 19914829

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