Ontology highlight
ABSTRACT:
SUBMITTER: Davis CW
PROVIDER: S-EPMC2818448 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Davis Christiana W CW Hawkins Brian J BJ Ramasamy Subbiah S Irrinki Krishna M KM Cameron Bruce A BA Islam Khalid K Daswani Varsha P VP Doonan Patrick J PJ Manevich Yefim Y Madesh Muniswamy M
Free radical biology & medicine 20091105 2
Nitric oxide (NO) and other reactive nitrogen species target multiple sites in the mitochondria to influence cellular bioenergetics and survival. Kinetic imaging studies revealed that NO from either activated macrophages or donor compounds rapidly diffuses to the mitochondria, causing a dose-dependent progressive increase in NO-dependent DAF fluorescence, which corresponded to mitochondrial membrane potential loss and initiated alterations in cellular bioenergetics that ultimately led to necroti ...[more]