Ontology highlight
ABSTRACT:
SUBMITTER: Upton JW
PROVIDER: S-EPMC4279434 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Upton Jason W JW Kaiser William J WJ Mocarski Edward S ES
Cell host & microbe 20100401 4
Viral infection activates cytokine expression and triggers cell death, the modulation of which is important for successful pathogenesis. Necroptosis is a form of programmed necrosis dependent on two related RIP homotypic interaction motif (RHIM)-containing signaling adaptors, receptor-interacting protein kinases (RIP) 1 and 3. We find that murine cytomegalovirus infection induces RIP3-dependent necrosis. Whereas RIP3 kinase activity and RHIM-dependent interactions control virus-associated necros ...[more]