Ontology highlight
ABSTRACT:
SUBMITTER: Sohn EJ
PROVIDER: S-EPMC2818579 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Sohn Eun Jung EJ Li Hongjie H Reidy Karen K Beers Lisa F LF Christensen Barbara L BL Lee Sean Bong SB
Cancer research 20100126 3
EWS/FLI1 is a fusion gene product generated by a chromosomal translocation t(11;22)(q24;q12) found in Ewing sarcoma. EWS/FLI1 encodes an aberrant transcription factor with oncogenic properties in vitro. Paradoxically, expression of EWS/FLI1 in nontransformed primary cells results in apoptosis, but the exact mechanism remains unclear. In primary mouse embryonic fibroblasts derived from conditional EWS/FLI1 knock-in embryos, expression of EWS/FLI1 resulted in apoptosis with concomitant increase in ...[more]